Endocrine Abstracts

Pseudohypoparathyroidism-1b (PHP-1b) is a genetically and biochemically distinct disorder characterised by selective PTH resistance limited to the kidney and lack of Albright Hereditary Osteodystrophy (AHO). Due to calcium mobilization from bone, patients with PHP-1b may remain asymptomatic and undiagnosed for a long time. Coexistent vitamin D deficiency sometime unmasks the clinical presentation of the disease.A 15-year-old Kuwaiti male presented with s...

The development of Leydig cells and steroidogenesis are controlled by activation of luteinizing hormone (LH) receptors by placental HCG during intrauterine life and by pituitary LH after birth. Naturally occurring isolated LH deficiency in man thus provide useful information to understand the intriguing role of this gonadotrophin.The patient was a 23 yr-old man from Afghanistan with a 46, XY karyotype. He presented with absent pubertal development and pr...